Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The six-hour injury response in lens epithelial cells

ABSTRACT: The six-hour injury response in lens epithelial cells

PROVIDER: PRJNA851377 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The six-hour injury response in lens epithelial cells

Project description:This trancriptome analysis reports genes that are differentially expressed in wildtype (WT) lens epithelial cells (LEC) between 6 hours and zero hours after injury.

2022-11-16 | GSE206563 | GEO

Injury response of human lens epithelial cells ex-vivo

Project description:This study investigates the response of human lens epithelial cells to mechanical injury. Human geriatric lenses obtained from cadaver eyes from donated to an eye bank for research were subject to in-vitro capsulotomy mimicking the injury sustained during cataract surgery. The anterior capsule was dissected using a curvilinear capsulorhexis technique, and central lens epithelial cells attached to the patch of anterior capsule (Rhexis) were immediately stabilized in RNAlater. The fiber cells were then removed, and the cortical fibers were immediately stabilized in RNA later. The remaining equatorial lens epithelial cells attached to the capsular bag from one eye were stabilized in RNA later immediately while the equatorial lens epithelial cells from the other eye were cultured for 24 hours then stabilized in RNAlater.

2024-10-27 | GSE186716 | GEO

Injury response of human lens epithelial cells ex-vivo

Project description:Injury response of human lens epithelial cells ex-vivo

| PRJNA775637 | ENA

The influence of sex and age on the lens injury response

Project description:The purpose of this study was to investigate/characterize age- and sex-dependent changes in transcriptomic profile in a mouse model of cataract surgery that mimics human cataract surgery. This surgery involves the removal of lens fiber cells (LFC) leaving behind the lens capsule and associated lens epithelial cells (LEC). The lens capsule and associated remnant LECs were harvested either following cataract surgery (0 hour) or 24 hours later. Fiber cells were collected at the time of surgery, equivalent to 0 hour, and analyzed separately from epithelial cells. For samples from LEC, each biological replicate is a pool of 5 lens capsules from 5 independent mice. For samples from LFC, each biological replicate is a pool of 2 fiber cell masses from two independent mice. Mice were either 24 months old (Aged), or 3 months old (Young).

2021-07-10 | GSE166619 | GEO

Lens epithelial cells transcriptome analysis

Project description:We performed RNAseq of passage 15 and passage 42 lens epithelial cell (FHL124), a lens epithelial cellular aging model.

2022-07-15 | GSE184422 | GEO

Lens Epithelial Cells and Lens Cortical Fiber Cells

Project description:Total RNA was isolated from three separate populations of human lens epithelial cells and three matching populations of lens cortical fiber cells. All samples were analyzed on separate microarrays. Keywords: repeat sample

2005-02-15 | GSE2256 | GEO

The role of Egr1 and FosB in the 6 hour injury response

Project description:This trancriptome analysis reports genes that are differentially expressed in wildtype (WT) lens epithelial cells (LEC) between 6 hours and zero hours after injury, and between Egr1 (E1) or FosB (FB) null LEC and wildtype LEC at zero hours (0H) and at 6 hours (6H) after injury.

2022-11-16 | GSE206574 | GEO

Transcription profiling of human lens epithelial cells and lens cortical fiber cells

2007-08-25 | E-GEOD-2256 | biostudies-arrayexpress

Lens epithelial cells transcriptome analysis

Project description:Lens epithelial cells transcriptome analysis

| PRJNA764592 | ENA

Six-hour interval time-course expression data during VISUAL

Project description:Six-hour interval time-course expression data during VISUAL

| PRJNA720046 | ENA