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The RNA binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance

ABSTRACT: The RNA binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance

PROVIDER: PRJNA851609 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19779037.fastq.gz	Fastqsanger.gz
	SRR19779038.fastq.gz	Fastqsanger.gz
	SRR19779039.fastq.gz	Fastqsanger.gz
	SRR19779040.fastq.gz	Fastqsanger.gz
	SRR19779041.fastq.gz	Fastqsanger.gz

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The RNA binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance

Project description:The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation have been extensively investigated, the role of post-transcriptional control is still poorly understood. Here we show that the nuclear activity of the RNA-binding protein Second Mitotic Wave Missing (Swm) is critical for Drosophila melanogaster intestinal stem cells (ISCs) and their daughter cells, enteroblasts (EBs), to maintain their progenitor cell properties and function. Loss of swm causes ISCs and EBs to stop dividing and instead detach from the basement membrane, resulting in severe progenitor cell loss. swm loss is furthermore characterized by nuclear accumulation of poly(A)+ RNA in progenitor cells. Swm associates with transcripts involved in epithelial cell maintenance and adhesion, and the loss of swm, while not generally affecting the levels of these Swm-bound mRNAs, leads to elevated expression of proteins encoded by some of them, including the fly ortholog of Filamin. Taken together, this study indicates a nuclear role for Swm in adult stem cell maintenance, raising the possibility that nuclear post-transcriptional gene regulation plays vital roles in controlling adult stem cell maintenance and function.

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