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ABSTRACT: Monkeypox Outbreak

PROVIDER: PRJNA860085 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR20698670_1.fastq.gz	Fastqsanger.gz
	SRR20698670_2.fastq.gz	Fastqsanger.gz
	SRR20715409_1.fastq.gz	Fastqsanger.gz
	SRR20715409_2.fastq.gz	Fastqsanger.gz

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Project description:Monkeypox outbreak 2022 Germany

| PRJEB53029 | ENA

Monkeypox Outbreak 2022 Spain ISCIII

Project description:Monkeypox Outbreak 2022 Spain ISCIII

| PRJEB53450 | ENA

Infection of MK2 cells with monkeypox virus

Project description:Orthopox viruses, including monkeypox, multiply intracellularly and induce numerous changes in host genes expression. The virus target mainly humoral host response, and simultaneously, exploits other genes and functions to reproduce effectively. The goal of this experiment is to identify those host genes and functions that are essential for monkeypox virus replication. Mock infected control cells were treated and incubated identically to time point arms, except for virus exposure. Two time points of cells infected with monkeypox virus were harvested at 3, 7 hours post infection, and gene expression was assessed using microarray in all arms. The experiment was done in triplicate.

2010-04-07 | E-GEOD-21001 | biostudies-arrayexpress

Infection of MK2 cells with monkeypox virus

2010-03-25 | GSE21001 | GEO

Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

Project description:The outbreak-causing monkeypox virus of 2022 (2022 MPXV) is classified as a clade IIb strain and phylogenetically distinct from prior endemic MPXV strains (clades I or IIa), suggesting that its virological properties may also differ. Here, we used human keratinocytes and induced pluripotent stem cell-derived colon organoids to examine the efficiency of viral growth in these cells and the MPXV infection-mediated host responses. MPXV replication was much more productive in keratinocytes than in colon organoids. We observed that MPXV infections, regardless of strain, caused cellular dysfunction and mitochondrial damage in keratinocytes. Notably, a significant increase in the expression of hypoxia-related genes was observed specifically in 2022 MPXV-infected keratinocytes. Our comparison of virological features between 2022 MPXV and prior endemic MPXV strains revealed signaling pathways potentially involved with the cellular damages caused by MPXV infections and highlights host vulnerabilities that could be utilized as protective therapeutic strategies against human mpox in the future.

2023-06-06 | GSE219036 | GEO

Project description:Second draft genome from Spain of the Monkeypox virus 2022 outbreak

| PRJNA844567 | ENA

Second draft genome from Spain of the Monkeypox virus 2022 outbreak

Project description:Second draft genome from Spain of the Monkeypox virus 2022 outbreak

| PRJEB53330 | ENA

Molecular and phylogenetic characterization of the monkeypox outbreak in Andalusia, Spain

Project description:Molecular and phylogenetic characterization of the monkeypox outbreak in Andalusia, Spain

| PRJEB55075 | ENA

Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus infected cells reveals virus-specific regulation of immune response genes

Project description:Orthopoxviruses are large DNA viruses which can cause disease in numerous host species. Even though the eradication of variola virus - the causative agent of human smallpox M-bM-^@M-^S succeeded, with the end of vaccinations several other orthopoxviruses emerged as potential threat to human health. For instance, animal-borne monkeypox virus, cowpox virus and closely related vaccinia virus are all capable of establishing zoonotic infections in humans. The disease caused by each virus differs in terms of expression and severity, but we still know little about the reasons for these different phenotypes. They may be explained by the unique repertoire of host cell modulating factors encoded by each virus. In this study, we aimed at characterizing the specific modulation of the host cells gene expression profile by orthopoxvirus infection. In our study we analyzed changes in host cell gene expression of HeLa cells after infection with cowpox virus, monkeypox virus or vaccinia virus and compared these to each other and to the gene expression profile of non-infected cells using Agilent Whole Genome Microarray technology. We could identify major differences in viral modulation of host cell immune response genes, especially an induction of genes involved in leukocyte migration and Toll-like receptor signalling in cowpox and monkeypox virus infected cells. This was not observed following vaccinia virus infection. If these differences contribute to the different clinical manifestation of cowpox, monkeypox and vaccinia virus infections in certain host species remains to be elucidated. We analyzed the gene expression profile of HeLa cells wich were either mock-infected or infected with Vaccinia virus strain IHD-W, Cowpox virus strain Brighton Red or Monkeypox virus strain MSF#6 at a multiplicity of infection of 5. Experiments were performed in duplicate. At 6 h post infection total RNA was isolated from infected cells and used for microarray analysis.

2012-04-14 | E-GEOD-36854 | biostudies-arrayexpress

ChIP-seq of human embryonic stem cells (hESCs) overexpressed with Monkeypox viral proteins H3L and A29L

Project description:We found that Monkeypox viral proteins H3L and A29L caused injuries in human cells. Whether they can bind chromatin and re-model chromation is unclear. Here, we applied ChIP-seq on hESCs to evaluate whether and how they are involved in chromatin regulation.

2024-08-28 | GSE239888 | GEO

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