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Microarray of Sirt1 KO and control astrocytes after cocktail stimulation

ABSTRACT: Microarray of Sirt1 KO and control astrocytes after cocktail stimulation

PROVIDER: PRJNA878473 | ENA |

REPOSITORIES: ENA

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Microarray of Sirt1 KO and control astrocytes after cocktail stimulation

Project description:The affection of Sirt1 on astrocyte is not well understanded. Here we studied the change of RNA expression profile after Sirt1 knockout in primary astrocyte after stimulating with A1 astrocyte inducing cocktails. To analyze the change of RNA expression profile after Sirt1 knockout in astrocytes, we built Sirt1 knockout and control astrocytes using crispr technique, and analyzed RNA expression profiles of Sirt1 KO and control astrocytes after treating with cocktail (C1q, IL-1α, TNF-α) by using microarray.

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Effect of IL-1α/TNFα/C1q Cocktail on gene expression of astrocytes

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Project description:We established a chemical cocktail that converts astrocytes into neuronal-like cells in vitro.

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Involvement of SIRT1-regulated transcription profiles in prostate cancer

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Effect of IL-1α/TNFα/C1q Cocktail on gene expression of astrocytes

Project description:To investigate the gene expression difference between resting astrocytes and C3d+ reactive astrocytes.

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RNAseq in Sirt1 wild-type or conditional KO mouse T-ALLs

Project description:C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-DE-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

2022-12-08 | GSE203387 | GEO

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)

Project description:Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in modulating hepatic circadian rhythmicity and aging. Sirt1-deficient mice exhibited profound premature aging and enhanced acetylation of histone H4 on lysine16 (H4K16) in the promoter of Per2, the latter of which leads to its overexpression; in turn, Per2 suppresses Sirt1 transcription through binding to the Sirt1 promoter at the Clock/Bmal1 site. This negative reciprocal relationship between SIRT1 and PER2 was also observed in human hepatocytes. We further demonstrated that the absence of Sirt1 or the ectopic overexpression of Per2 in the liver resulted in a dysregulated pace of the circadian rhythm. The similar circadian rhythm was also observed in aged wild type mice. The interplay between Sirt1 and Per2 modulates aging gene expression and circadian-clock maintenance.

2016-08-08 | GSE54436 | GEO

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)

2016-08-08 | E-GEOD-54436 | biostudies-arrayexpress

Transcriptome analysis of human astrocytes upon FGF1 stimulation

Project description:In a previous study performed in our laboratory, the level of FGF1 RNA was found to be increased in remyelinated multiple sclerosis lesions compared to control brain (unpublished observation). Astrocytes play a key role in multiple sclerosis lesion formation. To shed light on potential FGF1-mediated functions in multiple sclerosis, the impact of FGF1 on astrocytes was investigated.

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N6-methyladenosine (m6A) modification in HaCaT cells (immortalized human keratinocyte cell line) treated with STM2457 in the presence or absence of M5 (inflammatory factor cocktail) stimulation [MeRIPseq_KC]

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2024-08-20 | GSE268746 | GEO

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