Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mapping dynamic Tle3 distribution during CD8 T cell responses

ABSTRACT: Mapping dynamic Tle3 distribution during CD8 T cell responses

PROVIDER: PRJNA878819 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21504334_1.fastq.gz	Fastqsanger.gz
	SRR21504334_2.fastq.gz	Fastqsanger.gz
	SRR21504335_1.fastq.gz	Fastqsanger.gz
	SRR21504335_2.fastq.gz	Fastqsanger.gz
	SRR21504336_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Mapping dynamic Tle3 distribution during CD8 T cell responses

Project description:The goal of this study is to determine if central memory (Tcm) and effector memory (Tem) CD8 T cells can be reprogrammed to change their fate. We demonstrate that genetic ablation of Tle3 can promote generation of Tcm cells at the expense of Tem cells, and this can occur during the effector phase of the immune response.

2023-10-10 | GSE213036 | GEO

Impact of Tle3 induced deletion on transcriptomes of effector memory CD8 cells

2023-10-10 | GSE241532 | GEO

Adipose subtype-selective recruitment of TLE3 in thermogenic gene programs

Project description:Transcriptional effectors of white adipocyte-selective gene expression have not been described. TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective cofactor Prdm16 to specify lipid storage and thermogenic gene programs. When expressed at elevated levels in brown fat, TLE3 counters Prdm16, suppressing brown-selective genes and inducing white-selective genes, resulting in impaired fatty acid oxidation and thermogenesis. To further test the functional consequences of the changes in BAT phenotype in aP2-TLE3 Tg mice, we challenged them with cold exposure at 4C. aP2-TLE3 Tg mice had an impaired ability to respond to cold exposure compared to littermate control mice, as evidenced by a marked drop in core body temperature. Transgenic mice expressing TLE3 from the aP2 enhancer and wild type mice were housed individually without food and bedding immediately before the start of experiments. Mice were allowed free access to water and placed at 4C for 5 hours while core body temperature was monitored every hour using a rectal probe. For microarray experiments of BAT, RNA was extracted and pooled from 4 mice in each group.

2013-09-27 | E-GEOD-51223 | biostudies-arrayexpress

Impact of Tle3 induced deletion on chromatin accessibility profile of effector memory CD8 cells

2023-10-10 | GSE241533 | GEO

Reprogramming fate of central memory CD8+T cells by targetig the transcriptional coregulator Tle3 [scRNA-seq]

2023-10-10 | GSE216633 | GEO

The impact of Tbet and/or Runx3 deficiency on Tle3 binding pattern in early effector CD8 T cells

2023-10-10 | GSE241534 | GEO

Impact of Tle3 deficiency on memory T cell transcriptome

2023-10-10 | GSE213037 | GEO

Impact of Tle3 induced deletion on transcriptomes of effector memory CD8 cells

Project description:Impact of Tle3 induced deletion on transcriptomes of effector memory CD8 cells

| PRJNA1008605 | ENA

Impact of Tle3 deficiency on memory T cell chromatin accessbility landscape

2023-10-10 | GSE213035 | GEO

TLE3 CUT&Tag-Seq to characterize TLE3-binding sites in colonic macrophages

Project description:We found that TLE3 in colonic macrophages mainly occupied distal intergenic regions (48%) and gene body regions (47%) with limited occupancy at the gene proximal regions (5%).

2023-04-07 | GSE200645 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data