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Identify and eradicate leukemia stem cells in T-cell acute lymphoblastic leukemia by PD-1 therapy

ABSTRACT: Identify and eradicate leukemia stem cells in T-cell acute lymphoblastic leukemia by PD-1 therapy

PROVIDER: PRJNA890196 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21890700_1.fastq.gz	Fastqsanger.gz
	SRR21890700_2.fastq.gz	Fastqsanger.gz
	SRR21890683_1.fastq.gz	Fastqsanger.gz
	SRR21890683_2.fastq.gz	Fastqsanger.gz
	SRR21890684_1.fastq.gz	Fastqsanger.gz

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Identify and eradicate leukemia stem cells in T-cell acute lymphoblastic leukemia by PD-1 therapy

Project description:To investigate the characteristics of PD-1+ LSCs in T-ALL, we purified PD-1+ and PD-1– T-ALL cells from the bone marrow (femur and tibia) of T-ALL mice, Pten null T-ALL mice, or PDX recipients. RNA sequencing was performed to explore the differential gene expression and pathway enrichment of PD-1+ LSCs in T-ALL.

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