Ontology highlight
ABSTRACT:
PROVIDER: PRJNA923749 | ENA |
REPOSITORIES: ENA
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Project description:The research on alternative and sustainable feed ingredients is a challenge to reduce the feed-food competition between humans and monogastrics, in particular pigs. Former food products (FFPs) drop out from the industrial production of food such as pasta, bread, snacks and chips. They have a high nutritional and energetic value and represent an alternative and sustainable feed ingredient. The aim of this study was to apply label-free quantitative peptidomics to assess the impact of the inclusion of FFPs on serum peptidome.
2024-10-17 | PXD047855 | Pride
Project description:Intestinal inflammation, which is often observed in farmed salmon, is caused by anti nutrient in feed ingredients of plant origin. The aim of this study is to increase knowledge of this patholology and to assess effects of physiologically active compounds applied as feed additives.Feeding trial was followed with metabolomic, transcriptomic and bacterial meta genomic analyses.
2022-12-28 | GSE221800 | GEO
Project description:The research on alternative and sustainable feed ingredients is a challenge to reduce feed-food competition between humans and monogastrics, in particular pigs. Former food products (FFPs) drop out from the industrial production of food such as pasta, bread, snacks, and chips. They have a high nutritional and energetic value and represent an alternative and sustainable feed ingredient. The aim of this study was to apply omics tools to assess the impact of the dietary inclusion of FFPs in pigs’ diet. For the in vivo trial, thirty-six Swiss Large White male castrated pigs were randomly assigned to three dietary groups: control (CTR), 30% replacement of CTR diet with salty FFPs (SA), 30% replacement of CTR diet with sugary FFPs (SU). The trial lasted from the start of the growing phase (22.4 ± 1.7 kg) until slaughtering phase (110 ± 3 kg). After slaughtering, blood and liver tissue samples were collected and processed according to the omics approaches used. The number of differentially regulated proteins in each comparison matrix (SA/SU vs. CTR) indicated a marginal impact on liver function, as measured by proteomics on tissue samples. The peptidomics investigation on plasma samples showed low variability between the peptidome of the three dietary groups and identified three possible bioactive peptides associated with anti-hypertension in the SA dietary group. To conclude, the safety and the limited impact of the SA and SU diets on liver proteome and plasma peptidome strengthened the idea of recycling FFPs as feed ingredients to make pig production more sustainable.
2024-10-17 | PXD049972 | Pride
Project description:Unintentional use of mold-infested plant-based feed ingredients are sources of mycotoxins in fish feeds. The presence of the emerging mycotoxins ENNB and BEA in Norwegian commercial fish feeds and plant-based feed ingredients has raised concerns regarding the health effects on farmed Atlantic salmon (Salmon salar). Atlantic salmon pre-smolts were exposed to a non-lethal single-dose of BEA and ENNB, and total RNA sequencing of the intestine and liver was carried out to evaluate gut health and identify possible hepatological changes after a single-dose dietary exposure. ENNB and BEA did not give acute toxicity, however ENNB caused the onset of pathways linked to acute intestinal inflammation and BEA exposures caused the onset of hepatic hematological disruption. The prevalence and concentration of ENNB found in today's commercial feed could affect the fish health if consumed over a longer time-period.
2022-12-01 | GSE213817 | GEO
Project description:The gut microbiota is an essential contributor to human health and disease and offers an extensive resource of enzymes. Although functional metagenomics methods could predict a correlation between enzyme abundance and functional activity, many enzymes in the microbiome still remain uncharacterized. To discover the differing activities between similar annotated proteins in microbiome, approaches capable of detecting biochemical activity with identification of responsible microbes and enzymes are needed. α-Galactosidases (AGALs) are abundant in the host gut microbiota for hydrolysis of galactooligosaccharides, galactose-containing polysaccharides and glycoconjugates, and have multiple biotechnological applications with increasing demand of global AGAL market, such as food ingredients, animal feed, and biomedical sectors. However, many gut microbial AGALs still lack functional biochemical identification, which limits their usage in industrial and therapeutic applications.
2024-04-03 | PXD046454 | Pride
Project description:The study investigated the impact of environment on the composition of the gut microbiota and mucosal immune development and function at gut surfaces in early and adult life. Piglets of similar genotype were reared in indoor and outdoor environments and in an experimental isolator facility. Mucosa-adherent microbial diversity in the pig ileum was characterized by sequence analysis of 16S rRNA gene libraries. Host-specific gene responses in gut ileal tissues to differences in microbial composition were investigated using Affymetrix microarray technology and Real-time PCR. Experiment Overall Design: Animals were reared on the sow at an outdoor or indoor facility. Additional piglets from the indoor facility were transferred to individual isolator units at 24 hours of age, and given a daily dose of antibiotic cocktail for the duration of the study. Piglets were weaned at day 28. From day 29 onwards, piglets were fed creep feed ad libitum. Ileal tissue samples were excised from N=6 piglets per group at day 5, 28 and 56.
2009-12-05 | E-GEOD-15256 | biostudies-arrayexpress