Project description:This phase I clinical trial tests the immune effects of fermented wheat germ in patients with advanced solid tumor cancers who are being treated with standard of care checkpoint inhibitors. Fermented wheat germ is a nutritional supplement that some claim is a "dietary food for special medical purposes for cancer patients" to support them in treatment. There have also been claims that fermented wheat germ is "clinically proven" and "recognized by medical experts" to "enhance oncological treatment" and boost immune response to cancer; however, there are currently no documented therapeutic effects of fermented wheat germ as a nutritional supplement. Checkpoint inhibitors, given as part of standard of care for advanced solid tumors, are a type of immunotherapy that may help the body’s immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. The information gained from this trial may allow researchers to determine if there is any value of giving fermented wheat germ with standard of care checkpoint inhibitors for patients with advanced solid tumor malignancies.
| 68011 | ecrin-mdr-crc
Project description:Fermented corn-soybean meal and intestianl mucosa microbiota
Project description:In this study we conducted a randomized, controlled, cross-over single-meal study
comparing a meal with highly fermented yogurt and cheese, and a meal with beef
and pork meatballs. Postprandial urine samples from 17 subjects were collected
sequentially after each meal up to 24 hr and analyzed by untargeted metabolomics
through an UHPLC-qTOF.
Project description:We performed RNA-seq, H3K27ac ChIP-seq, and HNF4a ChIP-seq on jejunal intestinal epithelial cells, which are primarily responsible for the absorption of fatty acids, in four conditions: Germ-free (GF), Germ-free plus high fat meal (GF+HFM), ex-GF colonized with a conventional microbiota for 2 weeks (Colonized, CV), and Colonized plus high fat meal (CV+HFM). We, for the first time, map genomewide HFM responsive regulatory regions in the intestine. We identify that in the absence of microbes the HNF4a transcriptional program supports a FAO program in enterocytes while suppressing a proliferation program.
Project description:In this study we conducted a randomized, controlled, cross-over single-meal study
comparing a meal with highly fermented yogurt and cheese, and a meal with beef
and pork meatballs. Postprandial urine samples from 17 subjects were collected
sequentially after each meal up to 24 hr and analyzed by untargeted metabolomics
through an UHPLC-qTOF.
| MSV000095739 | GNPS
Project description:Fermented sunflower meal in diets for Atlantic salmon
