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Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure [human]

ABSTRACT: Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure [human]

PROVIDER: PRJNA985706 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24975907.fastq.gz	Fastqsanger.gz
	SRR24975908.fastq.gz	Fastqsanger.gz
	SRR24975909.fastq.gz	Fastqsanger.gz
	SRR24975910.fastq.gz	Fastqsanger.gz
	SRR24975911.fastq.gz	Fastqsanger.gz

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Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure

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Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure [human]

Project description:The diagnosis of Parkinsonism is based on motor symptoms that are caused by reduced dopaminergic output However, decades earlier, patients report non-motoric problems, including hyposmia It is not known if non-motor and motor defects are causally connected Here we used single-cell transcriptome sequencing (10x) of young and olf fly mutants (whole brain) and human patients (three regions: nucleus basalis of Meynert, nucleus accumbens and putamen). This atlas reveals early defects in cholinergic neurons that are recapitulaed across species

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Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure

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Proteomic analysis of secretory granules in dopaminergic neurons of Parkinson`s disease

Project description:Parkinson disease (PD) is the second most common age-related neurodegenerative disorder, which is related to neurotransmitter secretion impartment and the dysfunction of vesicle transport. Secretory granules (SGs) are a class of intracellular vesicles different from synaptic vesicles (SVs) in neurons and the neuroendocrine cells. They represent the primary subcellular site for the biosynthesis, storage and releasing of the neuropeptides, neurotransmitters and hormones. In the current study, we characterized the proteome of secretory granules in dopaminergic neurons in PD. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was used to identify proteins in SGs. A total of 4249 proteins were identified in the SGs in normal and MPP+-treated SH-Sy5Y dopaminergic neurons in total. This study regarded the biological alternations of SGs in PD as an entry point. By studying the significantly differentially expressed proteins, it is helpful to better understand the molecular mechanisms of SGs disorders in the pathology of PD, and provide a basis for vesicle transport theory in pathogenesis of PD.

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GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice

Project description:Heart failure and associated cachexia is an unresolved and important problem. We report a new model of severe heart failure that consistently results in cachexia. Mice lacking the integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A, exhibit a dilated cardiomyopathy and severe weight loss following irradiation, whilst wildtype mice are unaffected. This is associated with increased expression of Gdf15 in the heart and increased levels of GDF15 in the circulation. We provide evidence that blockade of GDF15 activity prevents cachexia and slows the progression of heart failure. Our data suggests that cardiac stress mediates a GDF15 dependent pathway that drives weight loss and worsens cardiac function. We show relevance of GDF15 to lean mass and protein intake with patients with heart failure. Blockade of GDF15 could constitute a novel therapeutic option to limit cardiac cachexia and improve clinical outcomes in patients with severe systolic heart failure.

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