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Analysis of skeletal muscle gene expression upon mouse hindlimb unloading and reloading

ABSTRACT: Analysis of skeletal muscle gene expression upon mouse hindlimb unloading and reloading

PROVIDER: PRJNA993705 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25238416_1.fastq.gz	Fastqsanger.gz
	SRR25238416_2.fastq.gz	Fastqsanger.gz
	SRR25238417_1.fastq.gz	Fastqsanger.gz
	SRR25238417_2.fastq.gz	Fastqsanger.gz
	SRR25238418_1.fastq.gz	Fastqsanger.gz

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Analysis of skeletal muscle gene expression upon mouse hindlimb unloading and reloading

Project description:To investigate the molecular mechanisms governing the transition of skeletal muscle from atrophy to compensatory regeneration and hypertrophy, we employed a mouse model involving hindlimb unloading and subsequent reloading, conducting a comprehensive analysis of global gene expression using RNA-sequencing (RNA-seq). Gastrocnemius muscle samples were obtained from three groups: control mice, mice subjected to 10 days of hindlimb unloading-induced muscle atrophy, and mice reintroduced to normal cage activity for 1 day following the unloading period (reloading).

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Project description:Examination of effect of mechanical loading induced by hindlimb suspension, and subsequent reloading, in soleus muscle in 14 day old female pathogen–free Wistar rats. Keywords = skeletal muscle Keywords = atrophy Keywords: other

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