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ProteomicsSuper-paramagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer growth
...onses in the tumor microenvironment. In this study, we propose super-paramagnetic iron oxide nanoparticles (SPIONs) as a promising anti-lung cancer adjuvant therapy to reduce tumor cell growth. We used SPIONs to target iron to macrophages and observed that SPION-loaded macrophages reduced tumor cell ...
ORGANISM(S): Mus Musculus (mouse) 
2024-04-18 | PXD040145 | Pride
Immunotherapy Lung cancer Iron Macrophages Spion 
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ProteomicsThe HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity
...toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated toxicity.
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2022-04-27 | PXD012612 | Pride
Yeast Alzheimer’s disease Lc-ms/ms Silac Saccharomyces cerevisiae 
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ProteomicsActivity-Guided Proteomic Profiling of Proteasomes - Whole proteome studies
A composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1) based on whole-cell proteomic analysis and to activity-guided proteasome profiling of indicates that the amounts of proteasomal proteins and proteasome intera...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-02-15 | PXD045047 | Pride
Activity-guided profilling Proteasome 
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ProteomicsSystematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Not available
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2012-07-26 | PRD000462 | Pride
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ProteomicsDetermination of the proteome of yeast cells during transition to quiescence
To identify proteins of Saccharomyces cerevisiae involved in the transition to quiescence in minimal buffered media, we compared the proteome of cells from exponential phase and a few hours after glucose-depletion.
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-12-13 | PXD041191 | Pride
Yeast Sigma1278b Saccharomyces cerevisiae Glucose depletion Quiescence 
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ProteomicsNε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 is Biased Towards Proteins Involved in Growth, Virulence and Antimicrobial Resistance
Protein acetylation is one of the post-translational modifications (PTMs) involved in regulating a myriad of cellular processes in bacteria. Increasing evidence demonstrates that lysine acetylation is involved in Mycobacterium tuberculosis (Mtb) virulence and pathogenesis. However, previous reports ...
ORGANISM(S): Mycobacterium Tuberculosis H37rv 
2018-05-02 | PXD006630 | Pride
o-acetylation. Mycobacterium tuberculosis nε-acetylation acetylome lineage 7 post-translational modifications Mycobacterium tuberculosis  lineage 7  post-translational modifications  acetylome  nε-acetylation  o-acetylation. 
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ProteomicsActivity-Guided Proteomic Profiling of Proteasomes
A composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1) based on whole-cell proteomic analysis and to activity-guided proteasome profiling of indicates that the amounts of proteasomal proteins and proteasome intera...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-02-15 | PXD045051 | Pride
Activity-guided profilling Proteasome 
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ProteomicsALLOSTERIC ACTIVATION OF A PLANT IMMUNE RECEPTOR KINASE COMPLEX
Receptor kinases (RKs) play fundamental roles in extracellular sensing to regulate development and stress responses across kingdoms. In plants, leucine-rich repeat receptor kinases (LRR-RKs) function primarily as peptide receptors that regulate myriad aspects of plant development and response to ext...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2021-10-27 | PXD025597 | Pride
Phosphorylation Innate immunity. Protein kinase Receptor kinase Pattern recognition receptor 
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Proteomics,MultiomicsYeast Bdf1 interactome - Bdf1 Bromodomains are Essential for Meiosis and the Expression of Meiotic-Specific Genes
Bromodomain and Extra-terminal motif (BET) proteins play a central role in transcription regulation and chromatin signalling pathways. In yeast, Bdf1 and its homologous protein Bdf2 are partially redundant and the deletion of both genes is lethal. Most of Bdf1 functions have been investigated in veg...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2017-01-11 | PXD005227 | Pride
Bdf1 Nanolc-ms/ms Saccharomyces cerevisiae Tap purification 
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ProteomicsHomogenization of tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization
Tissue samples from human tonsils and rat pancreas were subjected to a novel laser-based homogenization method, the PIRL-DIVE homogenization, and to a conventional mechanical tissue homogenization procedure (bead mill and a cryo-grinder). The protein species composition of the protein extracts were c...
ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human) 
2016-01-25 | PXD003434 | Pride
Sample preparation Lc-msms Proteolysis Pirl Tissue homogenization Pirl-dive Protein species 
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