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Proteomics293FT Cell Endogenous FANCA Protein-Protein Interactions
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a part o...
ORGANISM(S): Homo Sapiens (human) 
2019-07-25 | PXD010570 | Pride
Protein-protein interaction Fanca Fanconi anemia complementation group a 
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ProteomicsEndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to identify previously unexplored roles of...
ORGANISM(S): Homo Sapiens (human) 
2019-07-25 | PXD010589 | Pride
Human Pancreas beta cell Glucose stimulation 
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ProteomicsThe sex-specific factor SOA establishes X chromosome dosage compensation in Anopheles mosquitos
The Anopheles mosquito is one of thousands of species in which sex differences play a central role in their biology, as only females need a blood meal in order to produce eggs. Sex differentiation is regulated by sex chromosomes, but their presence creates a dosage imbalance between males (XY) and fe...
ORGANISM(S): Anopheles Gambiae (african Malaria Mosquito) 
2023-07-13 | PXD042353 | Pride
Lc-ms/ms 
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TranscriptomicsMaize primary roots: inbred lines vs. hybrids
The phenomenon of heterosis describes the increased agronomic performance of heterozygous F1-plants compared t...
...l 16 genotypes were paired on 85 arrays following a hybridization scheme including a dye-swap according to Keller et al. (2005). A tailor-made design was developed for this purpose using simulated annealing that was optimized for estimating non-additive effects while at the same time allowing estimation of additive effects with comparable precision. Optimizing precision for estimation of non-additivity required the design to be unbalanced with respect to the number of genotype pairings and the number of replications per genotype. Hence, two RNA samples were hybridized to each of the 85 microarray chips. Each RNA sample represented an independent biological replicate
ORGANISM(S): Zea mays 
2008-02-16 | E-GEOD-10539 | biostudies-arrayexpress
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Proteomics,MultiomicsPhosphoproteomic analyses reveal novel cross-modulation mechanisms between two signaling pathways in yeast
Cells respond to environmental stimuli via specialized signaling pathways. Concurrent stimuli trigger multiple pathways that integrate information, predominantly via protein phosphorylation. Budding yeast respond to NaCl and pheromone via two mitogen-activated protein kinase cascades, the high osmol...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2014-12-19 | PXD001445 | Pride
Signaling pathways Phospho-proteomics Budding yeast 
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ProteomicsAn Archaeal Pilus Survives the Most Extreme Conditions Through Extensive Glycosylation
Pili on the surface of Sulfolobus islandicus are used for a host of functions, and serve as receptors for certain archaeal viruses. We find that these pili, when removed from cells, resist digestion by trypsin or pepsin, and survive boiling in SDS or 5M guanidinium-HCl. We have used cryo-EM to determ...
ORGANISM(S): Sulfolobus Islandicus Lal14/1 
2020-05-26 | PXD012799 | Pride
Lc-ms Pili Cryo-em Glycosylation 
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ProteomicsCasID on RRM2 promoter region in neuroblastoma
dCas9-guided recruitment of the proximity ligation enzyme BirA* to the promoter region of RRM2 in SKNBE2c neuroblastoma cells.
ORGANISM(S): Homo Sapiens (human) 
2022-08-12 | PXD029630 | Pride
Bioid Rrm2 Neuroblastoma Casid 
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ProteomicsThe HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity
Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast ...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2022-04-27 | PXD012612 | Pride
Yeast Alzheimer’s disease Lc-ms/ms Silac Saccharomyces cerevisiae 
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Proteomics,MultiomicsIceman stomach content - The 5300-year-old Helicobacter pylori genome of the Iceman
Shotgun LC-MS/MS analysis of three stomach content samples of the Iceman, a 5300-year-old European glacier mummy.
ORGANISM(S): Homo Sapiens (human) 
2018-07-20 | PXD009565 | Pride
Proteins Mummy Diet Oetzi Hcd Shotgun Iceman Oge Stomach content Cid 
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UnknownNo Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
Not available
S-EPMC5085024 | biostudies-literature
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