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Sneyd2002_IP3_Receptor

ABSTRACT: This model was successfully tested on Jarnac and MathSBML. The model reproduces the time profile of "Open Probability" of the receptor as shown in Figure 4 of the publication. The value of calcium ion concentration "c" in this model is 10 microM. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000057 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
BIOMD0000000057?filename=BIOMD0000000057-biopax2.owl Owl
BIOMD0000000057?filename=BIOMD0000000057-biopax3.owl Owl
BIOMD0000000057?filename=BIOMD0000000057-matlab.m Other
BIOMD0000000057?filename=BIOMD0000000057-octave.m Other
BIOMD0000000057?filename=BIOMD0000000057.m Other
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Publications

A dynamic model of the type-2 inositol trisphosphate receptor.

Sneyd James J   Dufour Jean-Francois JF  

Proceedings of the National Academy of Sciences of the United States of America 20020212 4

The dynamic properties of the inositol (1,4,5)-trisphosphate (IP(3)) receptor are crucial for the control of intracellular Ca(2+), including the generation of Ca(2+) oscillations and waves. However, many models of this receptor do not agree with recent experimental data on the dynamic responses of the receptor. We construct a model of the IP(3) receptor and fit the model to dynamic and steady-state experimental data from type-2 IP(3) receptors. Our results indicate that, (i) Ca(2+) binds to the  ...[more]

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