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Keizer1996_Ryanodine_receptor_adaptation

ABSTRACT: The model reproduces the time profile of Open probability of the ryanodine receptor as shown in Fig 2A and 2B of the paper. The model was successfully tested on MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000060 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
BIOMD0000000060?filename=BIOMD0000000060-biopax2.owl Owl
BIOMD0000000060?filename=BIOMD0000000060-biopax3.owl Owl
BIOMD0000000060?filename=BIOMD0000000060-matlab.m Other
BIOMD0000000060?filename=BIOMD0000000060-octave.m Other
BIOMD0000000060?filename=BIOMD0000000060.m Other
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Publications

Ryanodine receptor adaptation and Ca2+(-)induced Ca2+ release-dependent Ca2+ oscillations.

Keizer J J   Levine L L  

Biophysical journal 19961201 6

A simplified mechanism that mimics "adaptation" of the ryanodine receptor (RyR) has been developed and its significance for Ca2+(-)induced Ca2+ release and Ca2+ oscillations investigated. For parameters that reproduce experimental data for the RyR from cardiac cells, adaptation of the RyR in combination with sarco/endoplasmic reticulum Ca2+ ATPase Ca2+ pumps in the internal stores can give rise to either low [Cai2+] steady states or Ca2+ oscillations coexisting with unphysiologically high [Cai2+  ...[more]

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