Ontology highlight
ABSTRACT:
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000059 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 1 - 5 of 15 |
American journal of physiology. Endocrinology and metabolism 20030318 1
We have developed a detailed mathematical model of ionic flux in beta-cells that includes the most essential channels and pumps in the plasma membrane. This model is coupled to equations describing Ca2+, inositol 1,4,5-trisphosphate (IP3), ATP, and Na+ homeostasis, including the uptake and release of Ca2+ by the endoplasmic reticulum (ER). In our model, metabolically derived ATP activates inward Ca2+ flux by regulation of ATP-sensitive K+ channels and depolarization of the plasma membrane. Resul ...[more]