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Locke2008_Circadian_Clock

ABSTRACT: The model reproduces Fig 2A of the paper. Model successfully reproduced using Jarnac and MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000185 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
BIOMD0000000185?filename=BIOMD0000000185-biopax2.owl Owl
BIOMD0000000185?filename=BIOMD0000000185-biopax3.owl Owl
BIOMD0000000185?filename=BIOMD0000000185-matlab.m Other
BIOMD0000000185?filename=BIOMD0000000185-octave.m Other
BIOMD0000000185?filename=BIOMD0000000185.m Other
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Publications

Global parameter search reveals design principles of the mammalian circadian clock.

Locke James C W JC   Westermark Pål O PO   Kramer Achim A   Herzel Hanspeter H  

BMC systems biology 20080229

<h4>Background</h4>Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle. The suprachiasmatic nucleus (SCN), which generates these ~24 h rhythms in mammals, consists of several thousand neurons. Each neuron contains a gene-regulatory network generating molecular oscillations, and the individual neuron oscillations are synchronised by intercellular coupling, presumably  ...[more]

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