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Sedaghat2002_InsulinSignalling_noFeedback

ABSTRACT: Model reproduces the various plots in Figure 6 and 7 of the paper. It was successfully tested on MathSBML. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

DISEASE(S): Diabetes Mellitus

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000137 | BioModels | 2024-09-02

REPOSITORIES: BioModels

Json Xml

Dataset's files

Source:
Action DRS
BIOMD0000000137?filename=BIOMD0000000137-biopax2.owl Owl
BIOMD0000000137?filename=BIOMD0000000137-biopax3.owl Owl
BIOMD0000000137?filename=BIOMD0000000137-matlab.m Other
BIOMD0000000137?filename=BIOMD0000000137.m Other
BIOMD0000000137?filename=BIOMD0000000137.ode Other
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Publications

A mathematical model of metabolic insulin signaling pathways.

Sedaghat Ahmad R AR   Sherman Arthur A   Quon Michael J MJ  

American journal of physiology. Endocrinology and metabolism 20021101 5

We develop a mathematical model that explicitly represents many of the known signaling components mediating translocation of the insulin-responsive glucose transporter GLUT4 to gain insight into the complexities of metabolic insulin signaling pathways. A novel mechanistic model of postreceptor events including phosphorylation of insulin receptor substrate-1, activation of phosphatidylinositol 3-kinase, and subsequent activation of downstream kinases Akt and protein kinase C-zeta is coupled with  ...[more]

PMID: 12376338

Publication: 1/4

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