Ontology highlight
ABSTRACT:
DISEASE(S): Diabetes Mellitus
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000137 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 1 - 5 of 14 |
American journal of physiology. Endocrinology and metabolism 20021101 5
We develop a mathematical model that explicitly represents many of the known signaling components mediating translocation of the insulin-responsive glucose transporter GLUT4 to gain insight into the complexities of metabolic insulin signaling pathways. A novel mechanistic model of postreceptor events including phosphorylation of insulin receptor substrate-1, activation of phosphatidylinositol 3-kinase, and subsequent activation of downstream kinases Akt and protein kinase C-zeta is coupled with ...[more]