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Ung2008_EGFR_Endocytosis

ABSTRACT: Model reproduces the various plots in the publication for "Control" concentrations. Model successfully tested on MathSBML.

SUBMITTER: Harish Dharuri

PROVIDER: BIOMD0000000205 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000205?filename=BIOMD0000000205-biopax2.owl	Owl
	BIOMD0000000205?filename=BIOMD0000000205-biopax3.owl	Owl
	BIOMD0000000205?filename=BIOMD0000000205-matlab.m	Other
	BIOMD0000000205?filename=BIOMD0000000205-octave.m	Other
	BIOMD0000000205?filename=BIOMD0000000205.m	Other

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Publications

Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.

Ung Choong Yong CY Li Hu H Ma Xiao Hua XH Jia Jia J Li Bao Wen BW Low Boon Chuan BC Chen Yu Zong YZ

FEBS letters 20080527 15

Deregulations of EGFR endocytosis in EGFR-ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c-Cbl-EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1. A mathematical model was developed to study how RhoA and ROCK regulate EGFR endocytosis. Our study suggested that over-expressing RhoA as well as ROCK prolon ...[more]

PMID: 18505685

Publication: 1/4

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