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Wounded versus nonwounded drosophila embryos

ABSTRACT: Elucidation of the wound response genes in Drosophila embryos Keywords: response to wounding wild-type drosophila embryos were wounded by laser ablation and compared to unwounded embryos.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Mark Winfield

PROVIDER: E-GEOD-10207 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos.

Stramer Brian B Winfield Mark M Shaw Tanya T Millard Thomas H TH Woolner Sarah S Martin Paul P

EMBO reports 20080314 5

By using a microarray screen to compare gene responses after sterile laser wounding of wild-type and 'macrophageless' serpent mutant Drosophila embryos, we show the wound-induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation-associated gene, growth arrest and DNA damage-inducible gene 45 (GADD45), is upregulated ...[more]

PMID: 18344972

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