Unknown,Transcriptomics,Genomics,Proteomics

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Hemocyte minus versus hemocyte plus drosophila embryos


ABSTRACT: Drosophila embryos that were lacking the hemocyte lineage were compared to wild-type embryos. Keywords: genetic modification Wild-type drosophila embryos were compared to serpent mutant embryos.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Mark Winfield 

PROVIDER: E-GEOD-10208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos.

Stramer Brian B   Winfield Mark M   Shaw Tanya T   Millard Thomas H TH   Woolner Sarah S   Martin Paul P  

EMBO reports 20080314 5


By using a microarray screen to compare gene responses after sterile laser wounding of wild-type and 'macrophageless' serpent mutant Drosophila embryos, we show the wound-induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation-associated gene, growth arrest and DNA damage-inducible gene 45 (GADD45), is upregulated  ...[more]

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