Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Jose Perez-Ortin
PROVIDER: E-GEOD-14077 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pelechano Vicent V Jimeno-González Silvia S Rodríguez-Gil Alfonso A García-Martínez José J Pérez-Ortín José E JE Chávez Sebastián S
PLoS genetics 20090821 8
Transcription elongation by RNA polymerase II was often considered an invariant non-regulated process. However, genome-wide studies have shown that transcriptional pausing during elongation is a frequent phenomenon in tightly-regulated metazoan genes. Using a combination of ChIP-on-chip and genomic run-on approaches, we found that the proportion of transcriptionally active RNA polymerase II (active versus total) present throughout the yeast genome is characteristic of some functional gene classe ...[more]