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AURATUS goldfish environmental genomics projects: fadrozole in the telencephalon

ABSTRACT: Sexually mature female goldfish were exposed (waterborne) to 50 ug/L fadrozole or untreated water (control) to examine the global gene expression of fadrozole on the telencephalon. A common reference design was used: 5 independent groups of telencephalonic tissue from sexually mature female goldfish exposed to 50 ug/L of waterborne fadrozole were hybridized against a common pool of unexposed fish. Slides 4, 14, 22, 33, 44.

ORGANISM(S): Carassius auratus

SUBMITTER: Vance Trudeau

PROVIDER: E-GEOD-14558 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Profiling neuroendocrine gene expression changes following fadrozole-induced estrogen decline in the female goldfish.

Zhang Dapeng D Popesku Jason T JT Martyniuk Christopher J CJ Xiong Huiling H Duarte-Guterman Paula P Yao Linhui L Xia Xuhua X Trudeau Vance L VL

Physiological genomics 20090609 3

Teleost fish represent unique models to study the role of neuroestrogens because of the extremely high activity of brain aromatase (AroB; the product of cyp19a1b). Aromatase respectively converts androstenedione and testosterone to estrone and 17beta-estradiol (E2). Specific inhibition of aromatase activity by fadrozole has been shown to impair estrogen production and influence neuroendocrine and reproductive functions in fish, amphibians, and rodents. However, very few studies have identified t ...[more]

PMID: 19509080

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