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AURATUS goldfish environmental genomics projects: SCH 23390 in the hypothalamus

ABSTRACT: Sexually regressing female goldfish were administered 2 i.p. injections: 1) 40 ug/g SCH 23390 in 0.1% DMSO and 0.6% saline, and; 2) 0.6% saline Tissues were harvested 5h post-injection. A common reference design was used: 4 independent groups of telencephali from sexually regressing female goldfish treated with 40 ug/g SCH 23390 hybridized against a common vehicle control. Slides 16, 24, 30, 35

ORGANISM(S): Carassius auratus

SUBMITTER: Jason Popesku

PROVIDER: E-GEOD-15708 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Meta-type analysis of dopaminergic effects on gene expression in the neuroendocrine brain of female goldfish.

Popesku Jason T JT Martyniuk Christopher J CJ Trudeau Vance L VL

Frontiers in endocrinology 20121102

Dopamine (DA) is a major neurotransmitter important for neuroendocrine control and recent studies have described genomic signaling pathways activated and inhibited by DA agonists and antagonists in the goldfish brain. Here we perform a meta-type analysis using microarray datasets from experiments conducted with female goldfish to characterize the gene expression responses that underlie dopaminergic signaling. Sexually mature, pre-spawning [gonadosomatic index (GSI) = 4.5 ± 1.3%] or sexually regr ...[more]

PMID: 23130016

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