Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Toru Kondo
PROVIDER: E-GEOD-17101 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hide Takuichiro T Takezaki Tatsuya T Nakatani Yuka Y Nakamura Hideo H Kuratsu Jun-ichi J Kondo Toru T
Cancer research 20091006 20
Recent findings have shown that malignant tumors contain cancer-initiating cells (CIC), which self-renew and are tumorigenic. However, CICs have not been characterized properly due to lack of specific markers. We recently established a mouse glioma cell line, NSCL61, by overexpressing an oncogenic HRas(L61) in p53-deficient neural stem cells. Using limiting dilution assays, we show that only 2 of 24 NSCL61 clones retained their tumorigenicity in vivo, although the others also expressed oncogenic ...[more]