Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

34 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Time course study of experimental cardiac hypertrophy in rat

ABSTRACT: To further investigate the role of hyaluronan and the regulation of its synthesis in cardiac hypertrophy, quantitative measurements of myocardial hyaluronan was correlated to gene transcription in hypertrophic cardiac tissue. Factor analysis was used to study correlation over time. Abdominal aorta was ligated in Wistar rats. Heart was excised 1 day, 6 days and 42 days after operation. Aorta ligated animals was compared to sham operated animals. N=6 in each time group, except aorta ligated after six days where n=5.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Urban Hellman

PROVIDER: E-GEOD-21600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic myocardium

Project description:Analysis of left venticular myocardium following morphine-induced sustained ligand activated preconditioning (SLP). Results provide insight into the molecular pathways affected by morphine-induced SLP in the pre- and post-ischemic heart. Total RNA obtained from isolated ventricular myocardium subjected to 5 days of morphine induced sustained ligand activated preconditioning (SLP) compared to placebo control ventricular myocardium, tissue collected pre- and post-ischemia (n=6/group).

2012-10-01 | E-GEOD-39407 | biostudies-arrayexpress

Histone posttranslational modifications and cell fate determination: Lens induction requires the lysine acetyltransferases CBP and p300

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-09-23 | E-GEOD-49219 | biostudies-arrayexpress

Gene regulation by Pax6 in the lens placode - E9.5

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-09-01 | E-GEOD-49230 | biostudies-arrayexpress

Cardiac Effects of Rosiglitazone in Male Wistar Rats

Project description:Rosiglitazone, a peroxisome proliferator-activated receptor g (PPARg) agonist of the thiazolidinedione class, is a major insulin-sensitizing drug widely used to treat type-2 diabetes. Rosiglitazone causes myocardial hypertrophy in rodents and increases the risk of cardiac events in man. To better characterize its cardiac effects, male Wistar rats were orally administered 0, 10 or 80 mg/kg/day rosiglitazone. Male Wistar rats were orally administered 0, 10 or 80 mg/kg/day rosiglitazone once per day for 14 days. Samples were obtained 6, 24, 168 or 336 hours after the final treatment.

2010-07-29 | E-GEOD-22553 | biostudies-arrayexpress

Gene regulation by Pax6 in the lens placode - E10.25

Project description:Wild type or Pax6 fx/fx; Le-Cre-positive surface ectoderm from E10.25 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified and reverse transcribed and amplified using a NuGEN kit. cDNA was biotinylated and hybridized to Illumina Mouse6 bead arrays. Three wild type and three knockout embryos were used. Each array used the cDNA obtained from the two prospective lens tissues from one embryo.

2013-09-23 | E-GEOD-49216 | biostudies-arrayexpress

Gene regulation by CBP-p300 in the lens placode - E10.5

Project description:Wild type or CBP/p300 fx/fx; Pax6-Cre-positive (CBP/p300-/-) surface ectoderm from E10.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified, pooled for each genotype and triplicate samples were reverse transcribed and amplified using a NuGEN kit. cDNA was biotinylated and hybridized to Illumina Mouse6v2.0 bead arrays. Three wild type and three knockout embryos were used. The RNA from embryos of the same genotype was purified and pooled and triplicate samples were amplified and used for microarray analysis.

2013-09-23 | E-GEOD-49218 | biostudies-arrayexpress

Gene regulation by CBP-p300 in the lens placode - E9.5

Project description:Wild type or CBP/p300 fx/fx; Le-Cre-positive (CBP/p300-/-) surface ectoderm from E9.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified, pooled for each genotype and triplicate samples were reverse transcribed and amplified using a NuGEN kit. cDNA was biotinylated and hybridized to Illumina Mouse6 v2.0 bead arrays. Three wild type and three knockout embryos were used. The RNA from embryos of the same genotype was purified and pooled and triplicate samples were amplified and used for microarray analysis.

2013-09-24 | E-GEOD-49223 | biostudies-arrayexpress

Gene regulation by Pax6 in the lens placode - E9.5 (3)

Project description:Wild type or Pax6 fx/fx; Le-Cre-positive (Pax6-/-) surface ectoderm from E9.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified, pooled for each genotype and triplicate samples were reverse transcribed and amplified using a NuGEN kit. cDNA was biotinylated and hybridized to Illumina Mouse6v2.0 bead arrays. Three wild type and three knockout embryos were used. The RNA from embryos of the same genotype was purified and pooled and triplicate samples were amplified and used for microarray analysis.

2013-09-01 | E-GEOD-49229 | biostudies-arrayexpress

Gene regulation by Pax6 in the lens placode - E9.5 (1)

Project description:Wild type or Pax6 fx/fx; Le-Cre-positive (Pax6-/-) surface ectoderm from E9.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified and reverse transcribed and amplified using a NuGEN kit. cDNA was biotinylated and hybridized to Illumina Mouse6 bead arrays. Three wild type and three knockout embryos were used. Each array used the cDNA obtained from the two prospective lens tissues (left and right eyes) from each embryo.

2013-09-01 | E-GEOD-49227 | biostudies-arrayexpress

Gene regulation by Pax6 in the lens placode - E9.5 (2)

2013-09-01 | E-GEOD-49228 | biostudies-arrayexpress