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Enhancer-like function for long non-coding RNAs in human

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Ulf Ørom

PROVIDER: E-GEOD-23549 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Long noncoding RNAs with enhancer-like function in human cells.

Ørom Ulf Andersson UA Derrien Thomas T Beringer Malte M Gumireddy Kiranmai K Gardini Alessandro A Bussotti Giovanni G Lai Fan F Zytnicki Matthias M Notredame Cedric C Huang Qihong Q Guigo Roderic R Shiekhattar Ramin R

Cell 20101001 1

While the long noncoding RNAs (ncRNAs) constitute a large portion of the mammalian transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been studied in any detail silence gene expression in processes such as X-inactivation and imprinting. We used a GENCODE annotation of the human genome to characterize over a thousand long ncRNAs that are expressed in multiple cell lines. Unexpectedly, we found an enhancer-like function for a set of these long ncRNAs in hum ...[more]

PMID: 20887892

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