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Murine Flt3L-derived dendritic cell-mediated early immune responses are critical to controlling cell-free HTLV-1 infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Saifur Rahman

PROVIDER: E-GEOD-24962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Murine FLT3 ligand-derived dendritic cell-mediated early immune responses are critical to controlling cell-free human T cell leukemia virus type 1 infection.

Rahman Saifur S Khan Zafar K ZK Wigdahl Brian B Jennings Stephen R SR Tangy Frederic F Jain Pooja P

Journal of immunology (Baltimore, Md. : 1950) 20101129 1

Human T cell leukemia virus type 1 (HTLV-1) is associated with two immunologically distinct diseases: HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia. We observed previously that depletion of dendritic cells (DCs) in CD11c-diphtheria toxin receptor transgenic mice followed by infection with cell-free virus led to greater proviral and Tax mRNA loads and diminished cellular immune response compared with mice infected with cell-associated virus. To understand the ...[more]

PMID: 21115731

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