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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

ABSTRACT: Genome-wide location analysis of transcription factor of c-Myc and Max was conducted using RenLab Hu6K array in Daudi cells. In comparison, the GWLA was also done for general transcription factor RNA polymerase II and TAF1, and sequence specific transcription factor E2F1 in the same cell line. Keywords = GWLA Keywords = RenLab Keywords = Hu6K Keywords = Myc Keywords = Max

ORGANISM(S): Homo sapiens

SUBMITTER: Zirong Li

PROVIDER: E-GEOD-2542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells.

Li Zirong Z Van Calcar Sara S Qu Chunxu C Cavenee Webster K WK Zhang Michael Q MQ Ren Bing B

Proceedings of the National Academy of Sciences of the United States of America 20030613 14

Overexpression of c-Myc is one of the most common alterations in human cancers, yet it is not clear how this transcription factor acts to promote malignant transformation. To understand the molecular targets of c-Myc function, we have used an unbiased genome-wide location-analysis approach to examine the genomic binding sites of c-Myc in Burkitt's lymphoma cells. We find that c-Myc together with its heterodimeric partner, Max, occupy >15% of gene promoters tested in these cancer cells. The DNA b ...[more]

PMID: 12808131

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