Molecular mechanisms of hepatocarcinogenesis in c-Myc/Tgfa transgenic mice

ABSTRACT: A complete understanding of molecular mechanisms that underlie cancer onset and progression could provide a basis to improve early diagnosis and more effective treatment. However, this is still a challenge in human, partly due to the difficulty of analyzing the early stages of the disease. In this context, genetically engineered mice represent a valuable alternative to model human carcinogenesis. Here, we studied cancer development in c-Myc/Tgfa transgenic mice that developed liver tumors which closely reproduce a subset of human hepatocellular carcinoma (HCC) with a poor prognosis. By using a functional genomics approach from early to late stages of HCC development, we demonstrated that hepatocarcinogenesis in c-Myc/Tgfa mice resulted from a progressive accumulation of transcriptional alt

ORGANISM(S): Mus musculus

SUBMITTER: Daekwan Seo 

PROVIDER: E-GEOD-25587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress