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Genomic alteration profiles of chronic type and acute type adult T-cell leukemia/lymphoma

ABSTRACT: Genomic aberration profiles of chronic type adult T-cell leuekemia/lymphoma (ATL) and acute type ATL(clinical samples) . The Cy3-labeled normal control DNA was obtained from peripheral blood mononuclear cells of healthy males.

ORGANISM(S): Homo sapiens

SUBMITTER: Noriaki Yoshida

PROVIDER: E-MTAB-1808 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clonal evolution of adult T-cell leukemia/lymphoma takes place in the lymph nodes.

Umino Akira A Nakagawa Masao M Utsunomiya Atae A Tsukasaki Kunihiro K Taira Naoya N Katayama Naoyuki N Seto Masao M

Blood 20110329 20

Adult T-cell leukemia/lymphoma (ATLL) is the neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). We performed oligo-array comparative genomic hybridization (CGH) against paired samples comprising peripheral blood (PB) and lymph node (LN) samples from 13 patients with acute ATLL. We found that the genome profiles of the PB frequently differed from those of the LN samples. The results showed that 9 of 13 cases investigated had a log2 ratio imbalance among chromosomes, and that chromoso ...[more]

PMID: 21447829

Publication: 1/2

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