Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ramesh Pillai
PROVIDER: E-GEOD-32183 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Reuter Michael M Berninger Philipp P Chuma Shinichiro S Shah Hardik H Hosokawa Mihoko M Funaya Charlotta C Antony Claude C Sachidanandam Ravi R Pillai Ramesh S RS
Nature 20111127 7376
Repetitive-element-derived Piwi-interacting RNAs (piRNAs) act together with Piwi proteins Mili (also known as Piwil2) and Miwi2 (also known as Piwil4) in a genome defence mechanism that initiates transposon silencing via DNA methylation in the mouse male embryonic germ line. This silencing depends on the participation of the Piwi proteins in a slicer-dependent piRNA amplification pathway and is essential for male fertility. A third Piwi family member, Miwi (also known as Piwil1), is expressed in ...[more]