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Whole genome bisulfite sequencing of idm1, rdd, ros1 mutants and Col-0 WT

ABSTRACT: Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in ros1, idm1, and rdd mutants and identify hypermethylated regions comparing to wild type Arabidopsis plants. Examination of 3 different mutants' methylome. 8 samples (3 mutants, 1 WT, each has two biological replicates)

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Jian-Kang Zhu

PROVIDER: E-GEOD-33071 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A histone acetyltransferase regulates active DNA demethylation in Arabidopsis.

Qian Weiqiang W Miki Daisuke D Zhang Heng H Liu Yunhua Y Zhang Xi X Tang Kai K Kan Yunchao Y La Honggui H Li Xiaojie X Li Shaofang S Zhu Xiaohong X Shi Xiaobing X Zhang Kangling K Pontes Olga O Chen Xuemei X Liu Renyi R Gong Zhizhong Z Zhu Jian-Kang JK

Science (New York, N.Y.) 20120601 6087

Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 an ...[more]

PMID: 22700931

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