Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Bacillus_anthracis_CGH


ABSTRACT: Analysis of genomic content of closely related Bacillus species. Refer to individual records for strain information. Refer to platform and individual sample records for experimental protocols.

ORGANISM(S): Bacillus anthracis

SUBMITTER: N Tourasse 

PROVIDER: E-GEOD-341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.

Read Timothy D TD   Peterson Scott N SN   Tourasse Nicolas N   Baillie Les W LW   Paulsen Ian T IT   Nelson Karen E KE   Tettelin Hervé H   Fouts Derrick E DE   Eisen Jonathan A JA   Gill Steven R SR   Holtzapple Erik K EK   Okstad Ole Andreas OA   Helgason Erlendur E   Rilstone Jennifer J   Wu Martin M   Kolonay James F JF   Beanan Maureen J MJ   Dodson Robert J RJ   Brinkac Lauren M LM   Gwinn Michelle M   DeBoy Robert T RT   Madpu Ramana R   Daugherty Sean C SC   Durkin A Scott AS   Haft Daniel H DH   Nelson William C WC   Peterson Jeremy D JD   Pop Mihai M   Khouri Hoda M HM   Radune Diana D   Benton Jonathan L JL   Mahamoud Yasmin Y   Jiang Lingxia L   Hance Ioana R IR   Weidman Janice F JF   Berry Kristi J KJ   Plaut Roger D RD   Wolf Alex M AM   Watkins Kisha L KL   Nierman William C WC   Hazen Alyson A   Cline Robin R   Redmond Caroline C   Thwaite Joanne E JE   White Owen O   Salzberg Steven L SL   Thomason Brendan B   Friedlander Arthur M AM   Koehler Theresa M TM   Hanna Philip C PC   Kolstø Anne-Brit AB   Fraser Claire M CM  

Nature 20030501 6935


Bacillus anthracis is an endospore-forming bacterium that causes inhalational anthrax. Key virulence genes are found on plasmids (extra-chromosomal, circular, double-stranded DNA molecules) pXO1 (ref. 2) and pXO2 (ref. 3). To identify additional genes that might contribute to virulence, we analysed the complete sequence of the chromosome of B. anthracis Ames (about 5.23 megabases). We found several chromosomally encoded proteins that may contribute to pathogenicity--including haemolysins, phosph  ...[more]

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