Dataset Information
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Martin Flück
PROVIDER: E-GEOD-4492 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional reprogramming during reloading of atrophied rat soleus muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 20050701 1
The hypothesis was tested that differential, coregulated transcriptional adaptations of various cellular pathways would occur early with increased mechanical loading of atrophied skeletal muscle and relate to concurrent damage of muscle fibers. Atrophy and slow-to-fast fiber transformation of rat soleus muscle was provoked by 14 days of hindlimb suspension (HS). Subsequent reloading of hindlimbs caused a fourfold increase in the percentage of muscle fibers, demonstrating endomysial tenascin-C st ...[more]
