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Sexual dimorphisms in zonal gene expression in mouse liver

ABSTRACT: Zone 1 and zone 3 areas were captured from mouse liver sections by laser capture microdissection Total RNA was isolated and gene expression profiles were determined using microarrays Six C3H/HeNCrlBR (C3H) mice, 3 male and 3 female mice were used. They were not treated in any way.

ORGANISM(S): Mus musculus

SUBMITTER: NIEHS Microarray Core

PROVIDER: E-GEOD-49707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sexual dimorphisms in zonal gene expression in mouse liver.

Saito Kosuke K Negishi Masahiko M James Squires E E

Biochemical and biophysical research communications 20130618 4

Many of the metabolic functions of the liver are localized either in the pericentral region (zone 3) or in the periportal region (zone 1). However, a systematic analysis of the heterogeneity and sexual dimorphism of gene expression in the liver is lacking. Our objective was to obtain sections of intact tissue from zone 1 and zone 3 from both male and female mouse liver, and to measure the patterns of gene expression in these sections. Zone 1 and zone 3 areas were isolated by laser capture microd ...[more]

PMID: 23791742

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