Differential gene expression in mouse skNAC knockout heart at E11.5
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chong Park
PROVIDER: E-GEOD-5841 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.
Park Chong Yon CY Pierce Stephanie A SA von Drehle Morgan M Ivey Kathryn N KN Morgan Jayson A JA Blau Helen M HM Srivastava Deepak D
Proceedings of the National Academy of Sciences of the United States of America 20101111 48
Cardiac and skeletal muscle development and maintenance require complex interactions between DNA-binding proteins and chromatin remodeling factors. We previously reported that Smyd1, a muscle-restricted histone methyltransferase, is essential for cardiogenesis and functions with a network of cardiac regulatory proteins. Here we show that the muscle-specific transcription factor skNAC is the major binding partner for Smyd1 in the developing heart. Targeted deletion of skNAC in mice resulted in pa ...[more]
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