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Transcriptomic analysis of src1 mutant

ABSTRACT: Gene expression analysis of a src1 yeast strain mutant and wt yeast strain growing in exponential phase in YPD Keywords: genetic modification Transcriptomic analysis of three independent replicates of wt and src1 yeast strain growing in exponential phase

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Jose Perez-Ortin

PROVIDER: E-GEOD-6370 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression.

Grund Stefanie E SE Fischer Tamás T Cabal Ghislain G GG Antúnez Oreto O Pérez-Ortín José E JE Hurt Ed E

The Journal of cell biology 20080901 5

Inner nuclear membrane proteins containing a LEM (LAP2, emerin, and MAN1) domain participate in different processes, including chromatin organization, gene expression, and nuclear envelope biogenesis. In this study, we identify a robust genetic interaction between transcription export (TREX) factors and yeast Src1, an integral inner nuclear membrane protein that is homologous to vertebrate LEM2. DNA macroarray analysis revealed that the expression of the phosphate-regulated genes PHO11, PHO12, a ...[more]

PMID: 18762579

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