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Hat mutants

ABSTRACT: Transcriptomes from the hat1, hat2 and hat1 hat2 mutants in S288C yeast background.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: JosÃ© PÃ©rez-OrtÃn

PROVIDER: E-GEOD-2434 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes.

Rosaleny Lorena E LE Antúnez Oreto O Ruiz-García Ana B AB Pérez-Ortín José E JE Tordera Vicente V

FEBS letters 20050801 19

HAT-B is a yeast histone acetyltransferase composed of Hat1, Hat2 and Hif1 proteins. We demonstrate that a hat2 mutant or a hat1hat2 double mutant, but not a hat1 mutant, have an extended life-span. Transcriptome analysis shows that the single hat mutants are not very different from wild type. However, the comparison of the hat1 and hat2 transcriptomes shows that they are different. The hat1hat2 double mutant shows a transcriptional phenotype similar to that of the hat1 mutant but strongly enhan ...[more]

PMID: 16023114

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