Unknown,Transcriptomics,Genomics,Proteomics

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Investigating GPR34 expression regulation using whole transcriptome sequencing of spleens and dendritic cells from wildtype and GPR34 knockout mice


ABSTRACT: Naive spleens as well as naive and LPS-treated dendritic cells from wildtype and GPR34-/- mice were sequenced to integrate expression profiles with protein interaction networks and find functional modules that are affected by GPR34 Expression profiles of dendritic cells and whole spleens were generated using Illumina HiSeq 2500/ Illumina HiScan

ORGANISM(S): Mus musculus

SUBMITTER: Torsten Schoneberg 

PROVIDER: E-GEOD-68155 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dendritic Cells Regulate GPR34 through Mitogenic Signals and Undergo Apoptosis in Its Absence.

Jäger Elisabeth E   Schulz Angela A   Lede Vera V   Lin Chen-Ching CC   Schöneberg Torsten T   Le Duc Diana D  

Journal of immunology (Baltimore, Md. : 1950) 20160205 6


Dendritic cells (DCs) are specifically equipped with the G protein-coupled receptor 34 (GPR34). Tight regulation of GPR34 gene expression seems highly important for proper immunological functions, because the absence of this receptor leads to an alteration of the immune response, whereas overexpression was reported to be involved in neuroinflammation. However, the regulatory mechanism of GPR34 expression has not yet been investigated. Whole-transcriptome RNA sequencing analysis from spleens and  ...[more]

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