Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse undifferentiated Dicer +/- (D4) and Dicer -/- (27H10) embryonic cell lines


ABSTRACT: We have analyzed the transcript expression levels in Dicer heterozygous and Dicer knock-out embryonic stem (ES) cells in order to identify which transcripts are regulated by RNAi pathway in mouse ES cells. Experiment Overall Design: Two cell lines were analysed in an undifferentiated state. Triplicates of both cell lines were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Lasse Sinkkonen 

PROVIDER: E-GEOD-7141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells.

Sinkkonen Lasse L   Hugenschmidt Tabea T   Berninger Philipp P   Gaidatzis Dimos D   Mohn Fabio F   Artus-Revel Caroline G CG   Zavolan Mihaela M   Svoboda Petr P   Filipowicz Witold W  

Nature structural & molecular biology 20080302 3


Loss of microRNA (miRNA) pathway components negatively affects differentiation of embryonic stem (ES) cells, but the underlying molecular mechanisms remain poorly defined. Here we characterize changes in mouse ES cells lacking Dicer (Dicer1). Transcriptome analysis of Dicer-/- cells indicates that the ES-specific miR-290 cluster has an important regulatory function in undifferentiated ES cells. Consistently, many of the defects in Dicer-deficient cells can be reversed by transfection with miR-29  ...[more]

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