Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

ABSTRACT: This series represents 52 tissues hybridized across 5 different chip patterns. Probes were placed at every exon-exon junction in each transcript. Keywords = junction alternate splicing oligonucleotide Keywords: parallel sample. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: John Castle

PROVIDER: E-GEOD-740 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

Johnson Jason M JM Castle John J Garrett-Engele Philip P Kan Zhengyan Z Loerch Patrick M PM Armour Christopher D CD Santos Ralph R Schadt Eric E EE Stoughton Roland R Shoemaker Daniel D DD

Science (New York, N.Y.) 20031201 5653

Alternative pre-messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are alternatively spliced. To understand the biological roles and regulation of alternative splicing across different tissues and stages of development, systematic methods are needed. Here, we demonstrate the use of microarrays to monitor splicing at every exon-exon junction in more than 10,000 multi-exon human genes in 52 tissues and cell lines. Thes ...[more]

PMID: 14684825

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Dataset Information

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

Publications

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

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