Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Leo Zeef
PROVIDER: E-MEXP-1744 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chadwick Nicholas N Zeef Leo L Portillo Virginia V Fennessy Carl C Warrander Fiona F Hoyle Sarah S Buckle Anne-Marie AM
Molecular cancer 20090609
<h4>Background</h4>Dysregulated Notch signalling is believed to play an important role in the development and maintenance of T cell leukaemia. At a cellular level, Notch signalling promotes proliferation and inhibits apoptosis of T cell acute lymphoblastic leukaemia (T-ALL) cells. In this study we aimed to identify novel transcriptional targets of Notch signalling in the T-ALL cell line, Jurkat.<h4>Results</h4>RNA was prepared from Jurkat cells retrovirally transduced with an empty vector (GFP-a ...[more]