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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Effect of 30 or 90 min exposure to endothelin-1 on the cardiac myocyte transcriptome

ABSTRACT: Cardiac myocytes were exposed to 100 nM endothelin-1 for 30 or 90 min to determine effects on mRNA expression using Exon arrays

ORGANISM(S): Rattus norvegicus

SUBMITTER: Angela Clerk

PROVIDER: E-MEXP-3393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.

Amirak Emre E Fuller Stephen J SJ Sugden Peter H PH Clerk Angela A

The Biochemical journal 20130301 2

ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >70% of the transcriptomic response to endothelin-1. In the present study we investigated the role of RSKs in the transcriptomic responses to the G(q)-protein-coupled receptor agonists endothelin-1, phenylephrine (a generic α(1)-adrenergic receptor ag ...[more]

PMID: 23215897

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