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Transcription profiling of known iron genes in liver, spleen and duodenum of C57BL/6J and SWR mouse strains which have low and high basal iron levels respectively

ABSTRACT: Comparison of expression of known 'iron' genes in liver, spleen and duodenum of C57BL/6J and SWR mouse strains which have low and high basal iron levels respectively.

INSTRUMENT(S): GenePix Professional 4200A [Axon Instruments]

ORGANISM(S): Mus musculus

SUBMITTER: Gemma Grant 

PROVIDER: E-MEXP-486 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multiple polymorphic loci determine basal hepatic and splenic iron status in mice.

Grant Gemma R GR   Robinson Susan W SW   Edwards Richard E RE   Clothier Bruce B   Davies Reginald R   Judah David J DJ   Broman Karl W KW   Smith Andrew G AG  

Hepatology (Baltimore, Md.) 20060701 1

Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in levels of non-heme iron, with C57BL/6J and SWR showing low and high levels, respectively. The genetic basis for this variability was examined using quantitative trait loci (QTL) analysis together with expression profiling and chromosomal positions o  ...[more]

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