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Transcription profiling of Salmonella enterica serovar Typhimurium exposure to triclosan

ABSTRACT: S. Typhimurium SL1344 was exposed to the minimum inhibitory concentration of triclosan and the transcriptomic response analysed.

ORGANISM(S): Salmonella enterica

SUBMITTER: Andrew Bailey 

PROVIDER: E-MEXP-2078 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification.

Bailey Andrew M AM   Constantinidou Chrystala C   Ivens Al A   Garvey Mark I MI   Webber Mark A MA   Coldham Nick N   Hobman Jon L JL   Wain John J   Woodward Martin J MJ   Piddock Laura J V LJ  

The Journal of antimicrobial chemotherapy 20090916 5

<h4>Objectives</h4>The use of triclosan within various environments has been linked to the development of multiple drug resistance (MDR) through the increased expression of efflux pumps such as AcrAB-TolC. In this work, we investigate the effect of triclosan exposure in order to ascertain the response of two species to the presence of this widely used biocide.<h4>Methods</h4>The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 and Escherichia coli K-12 MG1655 after exposure to th  ...[more]

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