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Transcription profiling of rat heart from a spontaneously hypertensive strain treated with doxorubicin or dexrazoxane and then doxorubicin

ABSTRACT: This study was initiated to characterize early DOX-induced changes in cardiac gene expression in order to identify potential additional areas for clinical intervention. Male spontaneously hypertensive rats (SHR) received 3 mg/kg DOX or vehicle (iv) 30 minutes following pretreatment with 50 mg/kg DZR or saline (ip) weekly for 1, 2 or 3 weeks.

ORGANISM(S): Rattus norvegicus

SUBMITTER: P Scott Pine

PROVIDER: E-MEXP-2071 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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