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Imprinting of the Polycomb Group Gene MEDEA Serves as a Ploidy Sensor in Arabidopsis

ABSTRACT: Comparison of fis2 and jas mutants and tetraploid x diploid crosses.

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Lars Hennig

PROVIDER: E-MEXP-2316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis.

Erilova Aleksandra A Brownfield Lynette L Exner Vivien V Rosa Marisa M Twell David D Mittelsten Scheid Ortrun O Hennig Lars L Köhler Claudia C

PLoS genetics 20090925 9

Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block." Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of ...[more]

PMID: 19779546

Similar Datasets

Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis.

Project description:Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block." Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues.

| S-EPMC2738949 | biostudies-literature

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Project description:Hepatitis C virus (HCV) RNA synthesis and protein expression affect cell homeostasis by modulation of gene expression. The impact of HCV replication on global cell transcription has not been fully evaluated. Thus, we analysed the expression profiles of different clones of human hepatoma-derived Huh7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system). First, we compared the expression profile of HCV replicon clone 21-5 with both the Huh-7 parental cells and the 21-5 cured (21-5c) cells. In these latter, the HCV RNA has been eliminated by IFN-? treatment. To confirm data, we also analyzed microarray results from both the 21-5 and two other HCV replicon clones, 22-6 and 21-7, compared to the Huh-7 cells. The study was carried out by using the Applied Biosystems (AB) Human Genome Survey Microarray v1.0 which provides 31,700 probes that correspond to 27,868 human genes. A total of 15 hybridization were performed, allowing to compare transcription profiles among the following groups of cell lines: - HCV replicon clone: 21-5 (4 hybs) - cured HCV replicon clone: 21-5c (4 hybs) - parental cell line: Huh-7 (4 hybs) - other HCV replicon clones: 21-7 (2 hybs); 22-6 (1 hyb)

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Project description:Expression profiling of sum1 delta strain at three time points after the start of meiosis

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