Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of ApoE3Leiden mice exposed to high doses of cholesterol and one of three atherosclerosis drugs rosuvastatin, fenofibrate and T0901317 in order to compare atherosclerosis therapeutics

ABSTRACT: A study of the effects of dietary cholesterol and drug treatment on atherosclerotic lesion development using ApoE3Leiden mice

ORGANISM(S): Mus musculus

SUBMITTER: Svetlana Bureeva

PROVIDER: E-MEXP-3282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.

Kleemann Robert R Bureeva Svetlana S Perlina Ally A Kaput Jim J Verschuren Lars L Wielinga Peter Y PY Hurt-Camejo Eva E Nikolsky Yuri Y van Ommen Ben B Kooistra Teake T

BMC systems biology 20110812

<h4>Background</h4>Successful drug development has been hampered by a limited understanding of how to translate laboratory-based biological discoveries into safe and effective medicines. We have developed a generic method for predicting the effects of drugs on biological processes. Information derived from the chemical structure and experimental omics data from short-term efficacy studies are combined to predict the possible protein targets and cellular pathways affected by drugs.<h4>Results</h4 ...[more]

PMID: 21838869

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Dataset Information

Transcription profiling of ApoE3Leiden mice exposed to high doses of cholesterol and one of three atherosclerosis drugs rosuvastatin, fenofibrate and T0901317 in order to compare atherosclerosis therapeutics

Publications

A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.

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