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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human heart tissue to identify sex-specific differences in ventricular gene expression between men and women with aortic stenosis

ABSTRACT: The purpose of this study was to assess the impact of sex on gene expression in LV of AS patients at the time of AVR. LV samples of men (n = 9; age: 75 M-1 8 y) and women (n = 10; age: 72 M-1 9 y) undergoing AVR were used for RNA isolation. Genome-wide expression profiling was performed using the Affymetrix platform and the data were analyzed with R and Bioconductor. Diseased samples were compared with LV samples of men (n = 10; age: 56 M-1 4 y) and women (n = 8; age: 56 M-1 5 y) with no apparent cardiovascular disorder.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Georgios Kararigas

PROVIDER: E-MEXP-3684 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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