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ChIP-chip study aimed at the identification of the repertoire of FOXC2 binding sites affected by the loss of FOXC2 phosphorylation in primary human lymphatic endothelial cells (LECs)

ABSTRACT: Chromatin immunoprecipitation microarray (ChIP-chip) study using anti-Myc (9E10) antibodies and primary human lymphatic endothelial cells (LECs) transduced with recombinant adenoviruses expressing wild type or phosphorylation-deficient Myc-tagged FOXC2.

ORGANISM(S): Homo sapiens

SUBMITTER: Tatiana Petrova

PROVIDER: E-MTAB-596 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.

Ivanov Konstantin I KI Agalarov Yan Y Valmu Leena L Samuilova Olga O Liebl Johanna J Houhou Nawal N Maby-El Hajjami Hélène H Norrmén Camilla C Jaquet Muriel M Miura Naoyuki N Zangger Nadine N Ylä-Herttuala Seppo S Delorenzi Mauro M Petrova Tatiana V TV

Molecular and cellular biology 20130722 19

One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development. However, the mechanisms regulating FOXC2 transcriptional activity are not well understood. We report here that FOXC2 is phosphorylated on eight evolutionarily conserved proline-directed seri ...[more]

PMID: 23878394

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